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Major hemolytic reactions usually occur within
the first 50 mls of a blood transfusion

    This is why it is critical to observe the patient continuously during this period and obtain vital signs 15 minutes into the transfusion. Please note that pre-infusion and 15 minute vital sign documentation now includes temperature, blood pressure, heart rate, respiratory rate and O2 saturation.

    • In Pediatrics, closely observe the patient for the first 15 to 30 minutes of the infusion.

    • In neonates, monitor the patient at least every 1 hour until transfusion is infused.

    Patients may not leave the unit with blood products running unless accompanied by an RN or MD, and only in emergency situations or pre-procedure (ie Head CT to R/O bleed).

    Always document vital signs at the completion of the transfusion on the Blood Bank Transfusion Record as well.

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    UCSF Medical Center - Special Procedures: Blood Transfusion Reactions
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